Endocrine Abstracts

Selenium is an essential element for humans. Important dietary sources of selenium include meat, seafood, and grains. Selenium is incorporated into a range of selenoenzymes with antioxidant properties. Being crucial for the activity of the deiodinase enzymes, selenium is especially important for the synthesis and metabolism of thyroid hormones. Selenium in relation to thyroid diseases has been widely explored. Epidemiological studies have shown that a low selenium status is as...

Background: Hyperthyroidism as well as hypothyroidism have been associated with oxidative stress, caused by an imbalance between pro-oxidants and antioxidants. Oxidative stress may damage the genomic apparatus and other cellular structures. Urinary excretion of 8-oxo-7.8-dihydroguanosine (8-oxoGuo) and 8-oxo-7.8-dihydro-2’-deoxyguanosine (8-oxodG), respectively, represent global RNA and DNA oxidation, thus reflecting oxidatively generated modification of nucleic acids in...

PurposeThe standard treatment of hypothyroidism is levothyroxine (LT4), which is available as tablets or soft-gel capsules in Denmark. This study aimed to investigate Danish endocrinologists’ use of thyroid hormones in hypothyroid and euthyroid patients.MethodAn e-mail with an invitation to participate in an online survey investigating practices about substitution with thyroid hormones was sent to all me...